TB-500

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Lyophilized TB-500 Powder

Key Features

• Actin Dynamics & Cell Migration
  TB-500 binds G‑actin monomers to regulate filament turnover, promoting rapid fibroblast and endothelial cell migration into injury sites PMC.

• Accelerated Wound Closure
  In full‑thickness rodent wound models, topical or systemic TB-500 treatment led to significant increases in wound contraction (≥ 11 %) and re‑epithelialization over saline controls PubMed.

• Enhanced Angiogenesis
  TB-500 up‑regulates VEGF expression and integrin‑linked kinase pathways, driving new blood‑vessel formation essential for tissue repair PubMed.

• Anti‑Inflammatory Modulation
  The peptide reduces pro‑inflammatory cytokine expression and limits NF‑κB activation, thereby minimizing edema and oxidative stress in preclinical assays PubMed; PubMed.

• Tissue Remodeling Support
  TB-500 enhances collagen deposition and keratinocyte migration, resulting in stronger, more organized dermal and musculoskeletal repair PMC.

Applications

• Wound‑Healing Models
  Quantify closure rates, re‑epithelialization, and scar quality in rodent and organotypic skin models ScienceDirect.

• Angiogenesis & Vascular Research
  Probe endothelial sprouting, lumen formation, and perfusion enhancement in ex vivo and in vitro angiogenesis assays BioMed Central.

• Tendon & Muscle Regeneration
  Assess fibroblast survival, actin‑mediated cell motility, and collagen organization in tendon and muscle injury paradigms PubMed.

• Inflammation & Oxidative Stress Studies
  Use as a modulator of NF‑κB signaling and cytokine release in immune cell and epithelial cell assays PubMed.

• Formulation & Pharmacokinetics
  Develop and validate analytical methods for TB-500 quantification and delivery system optimization in in vitro and in vivo contexts ScienceDirect.

Specifications