Semax

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Lyophilized Semax Powder

Overview

Semax (Met–Glu–His–Phe–Pro–Gly–Pro) is a modified fragment of adrenocorticotropic hormone designed to resist peptidase degradation, enabling central nervous system penetration and prolonged activity PubMed Central. In rodent models of ischemic stroke, Semax reduced infarct size and improved neurological outcomes when administered intraperitoneally MDPI. Human pilot studies demonstrate that single intranasal doses enhance resting‑state default mode network connectivity and boost short‑term memory and attention in healthy volunteers PubMedAlzheimer's Drug Discovery Foundation.

Key Features

• BDNF & NGF Up‑Regulation: Semax increases hippocampal BDNF protein by ~1.4‑fold and trkB phosphorylation within 90 min, supporting synaptic plasticity and learning PubMedPubMed.

• Rapid Anxiolytic Action: Modulates GABA_A receptor affinity to deliver fast‑onset stress relief without sedation or tolerance seen with benzodiazepines PubMedFrontiers.

• Neuroprotection: Protects neurons from ischemic and excitotoxic insults, reducing post‑stroke damage via antioxidant and anti‑inflammatory pathways MDPIResearchGate.

• Cognitive Enhancement: Improves attention, working memory, and executive function in fatigued healthy subjects and patients recovering from brain injury WikipediaAlzheimer's Drug Discovery Foundation.

• Clean Safety Profile: Extensive use in Russian clinical settings reports minimal adverse events and no dependence or withdrawal PubMed CentralResearchGate.

Applications

• Stroke & Neuroprotection Models: Evaluate infarct reduction, behavioral recovery, and molecular markers in rodent ischemia/reperfusion paradigms MDPIResearchGate.

• Anxiety & Stress Research: Use in in vivo assays to probe GABAergic modulation, HPA‑axis regulation, and stress‑related gene expression PubMedFrontiers.

• Cognitive & Fatigue Studies: Apply in animal models of cognitive fatigue to measure improvements in attention, memory retention, and neural network connectivity PubMedAlzheimer's Drug Discovery Foundation.

• Neurotrophic Mechanism Exploration: Investigate BDNF/NGF induction pathways, neurogenic gene expression, and synaptic remodeling post‑Semax administration PubMedResearchGate.

• Peptide Stability & Delivery: Optimize intranasal formulations, pharmacokinetics, and CNS delivery methods for rapid‑action neuropeptides PubMed Centralenhancedwellnessny.com.

Specifications