NAD+

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Lyophilized Buffered Nicotinamide Adenine Dinucleotide (NAD⁺) Powder

Key Features

• Purity (HPLC‑Verified): Reverse‑phase HPLC methods provide accurate, reproducible quantification of NAD⁺ levels in cells and tissues PMC.

• Buffered Formulation: Pre‑buffered to physiological pH (7.2–7.4), reducing pH‑related assay variability and eliminating the need for additional buffering agents.

• Lyophilized Format: Freeze‑drying maximizes chemical stability and shelf life by minimizing hydrolytic degradation; correctly stored, lyophilisates remain stable for months to years.

• Dual Redox Capacity: Functions as both oxidized (NAD⁺) and reduced (NADH) forms, enabling efficient electron transfer in oxidative phosphorylation and supporting ATP synthesis PMC.

• Enzyme Cofactor: Activates sirtuin‑mediated deacetylation and PARP‑dependent ADP‑ribosylation to maintain genomic stability and cellular stress resilience PMC.

• Low Endotoxin: Validated for in vitro cell culture use without triggering confounding immune responses PMC.

Applications

• Cell Culture Supplement: Prevents NAD⁺ depletion artifacts in neuronal, immune, and stem cell models by replenishing intracellular pools PMC.

• Metabolic & Aging Research: Models senescence and evaluates interventions targeting NAD⁺‑dependent longevity pathways in vitro and in vivo PMC.

• Enzymatic & ELISA Standards: Serves as a precise substrate or cofactor in kinetic assays for sirtuins, PARPs, and dehydrogenases Nature.

• Synthetic Biology & Biochemical Engineering: Integrates into bioreactors and microfluidic systems requiring tight redox control and coenzyme recycling Analytical Science Journals.

• Pharmacokinetic Modeling: Enables accurate NAD⁺ dosing in ADME/Tox studies to probe metabolic stability and degradation pathways PMC.

Specifications

Links to previous studies:

The Role of NAD+ in Regenerative Medicine

Drugs Targeting Mechanisms of Aging