IGF‑1LR3

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Lyophilized IGF‑1LR3 Powder

Overview

Insulin‑like Growth Factor‑1 Long Arg3 (IGF‑1LR3) is a synthetic analog of native IGF‑1 engineered for extended activity and enhanced potency in research applications. By substituting arginine at position 3 and adding 13 amino acids at the N‑terminus, IGF‑1LR3 resists binding protein sequestration and proteolysis, resulting in a half‑life of 20–30 hours versus 12–15 minutes for natural IGF‑1 Wikipedia. It retains full agonist activity at the IGF‑1 receptor to promote anabolic and mitogenic signaling, making it ideal for studies in muscle biology, metabolic regulation, and cell survival pathways PMC.

Key Features

• Extended Half‑Life & Potency
  The N‑terminal extension and Arg³ substitution increase metabolic stability and reduce IGFBP affinity, boosting potency roughly threefold over native IGF‑1 with a circulating half‑life of 20–30 hours Wikipedia Swolverine.

• Anabolic & Mitogenic Activity
  Activates the IGF‑1 receptor to stimulate PI3K‑Akt and MAPK pathways, driving protein synthesis, cell proliferation, and survival in muscle and non‑muscle cell models PMC.

• Low Binding to IGFBPs
  Reduced affinity for IGF‑binding proteins ensures more free peptide available to engage receptors, enhancing bioactivity in vitro and in vivo assays Wikipedia.

• Versatile Delivery
  Supplied as a sterile, lyophilized powder that reconstitutes easily in aqueous buffer; suitable for subcutaneous injection, infusion pumps, or formulation into controlled‑release systems Swolverine.

• High Purity & Quality Control
  Verified ≥ 99 % purity by reverse‑phase HPLC and mass spectrometry; manufactured under cGMP‑equivalent conditions to ensure batch‑to‑batch consistency Qkine.

Research Applications

• Muscle Growth & Regeneration
  Model IGF‑1–mediated myoblast differentiation, protein synthesis, and recovery after injury in cell culture and rodent models PMC LIVV.

• Metabolic & Aging Studies
  Investigate IGF‑1 LR3’s effects on glucose uptake, insulin sensitivity, and age‑related decline in mitochondrial function LIVV.

• Stem Cell Maintenance
  Support proliferation and pluripotency in human stem cell cultures, reducing differentiation and apoptosis Qkine.

• Neuroprotection & Cognitive Research
  Explore IGF‑1 signaling in models of neurodegeneration, synaptic plasticity, and neuronal survival under stress PMC.

• Cancer Biology & Signal Transduction
  Examine mitogenic signaling, receptor trafficking, and downstream gene expression in tumor and normal cell lines PubMed.

Specifications