BPC‑157 + TB‑500 Blend

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Overview

The BPC‑157 + TB‑500 blend is a lyophilized formulation containing equimolar amounts of gastric pentadecapeptide BPC‑157 and thymosin β4-derived TB‑500, designed for precise in vitro and in vivo dosing PMCPubMed. BPC‑157 is a 15‑amino‑acid fragment from human gastric juice shown to accelerate wound healing, tendon outgrowth, and gut lining repair PubMedPhysiology Journals. TB‑500, a synthetic peptide mimicking thymosin β4, promotes angiogenesis, endothelial cell migration, and tissue regeneration via actin regulation PubMedBiotech Peptides.

Key Features

• Fibroblast & Collagen Activation: BPC‑157 up‑regulates fibroblast outgrowth and collagen I/III synthesis in tendon and dermal models, improving structural repair PubMedScienceDirect.

• Gut & Mucosal Protection: BPC‑157 enhances mucosal integrity and accelerates healing in GI injury models, making it valuable for gut‑healing assays PMCPubMed.

• Angiogenesis & Vascular Repair: TB‑500 stimulates new blood‑vessel formation by activating integrin‑linked kinase and promoting endothelial migration in wound models PubMedPMC.

• Cell Migration & Remodeling: TB‑500 regulates actin dynamics, enhancing cell motility and tissue remodeling in muscle and skin injury assays.

• Anti‑Inflammatory Effects: Both peptides suppress pro‑inflammatory cytokines and NF‑κB signaling, reducing edema and oxidative stress in preclinical studies PMCMDPI.

Applications

• Tendon & Ligament Repair Models: Study fibroblast survival, outgrowth, and biomechanical restoration in tendon explants and injury models PubMedPhysiology Journals.

• Wound Healing Assays: Quantify re‑epithelialization, angiogenesis, and collagen deposition in scratch and excision wound models Dove PressPubMed.

• Muscle & Skin Regeneration: Evaluate muscle fiber repair, scar reduction, and barrier function in 3D skin equivalents and muscle injury studies Jeffrey Peng MDPubMed.

• Vascular Biology: Probe endothelial cell differentiation, neovascularization, and vascular integrity in cardiovascular and ischemia models PubMedThe Times of India.

• Inflammation & Oxidative Stress Research: Use as a tool to mitigate LPS‑induced cytokine release and ROS generation in immune and epithelial cell lines PMCMDPI.

Specifications