Selank

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Lyophilized Selank Powder

Overview

Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin that exerts potent anxiolytic, cognitive‑enhancing, and neuroprotective effects without the sedation or dependency risk of benzodiazepines PMCPMC. Intranasal administration allows rapid brain delivery and has been shown to modulate GABA_A receptor affinity, balancing inhibitory neurotransmission for fast‑acting stress relief PMCPubMed.

Key Features

• Anxiolytic Efficacy: Clinical trials in patients with generalized anxiety disorder and neurasthenia demonstrated that Selank’s effect on psychometric scales is comparable to low‑dose benzodiazepines, but without cognitive impairment or tolerance buildup PubMed.

• GABAergic Modulation: Enhances GABA_A receptor binding affinity and alters the expression of GABAergic neurotransmission genes, stabilizing neuronal excitability under stress PMCResearchGate.

• Cognitive Enhancement: In both animal models and healthy human volunteers, Selank increases BDNF levels in the hippocampus and cortex, improving memory formation, attention, and executive function PubMedPubMed.

• Mood & Neuroprotection: By up‑regulating neurotrophic factors and balancing monoamines (serotonin, dopamine), Selank provides rapid mood elevation and protects against neurotoxic insults PMCFrontiers.

• Safety & Tolerability: Across multiple studies—including comparisons with phenazepam—Selank shows minimal side effects (mild nasal irritation, transient headache) and no dependency potential PubMedPMC.

Applications

• Anxiety Models: Precise modulation of GABAergic tone in rodent and human tissue assays to investigate novel anxiolytic mechanisms PMC.

• Cognitive Research: Use in memory and learning paradigms to study BDNF‑mediated synaptic plasticity and neurogenesis PubMed.

• Stress & Depression Studies: Probe neuroendocrine regulation of stress responses and mood disorders via tuftsin analog pathways PMC.

• Neuroprotection Assays: Test against excitotoxic or ischemic injury models to evaluate protective gene‑expression profiles Frontiers.

• Gene Expression & Epigenetics: Examine impact on expression of GABAergic and neurotrophic genes using in vitro neuronal cultures ResearchGate.

Specifications