PE 22-28

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Lyophilized PE 22-28 Peptide Powder

Key Features

• Selective Anxiolytic Activity
  PE 22-28 is a synthetic fragment of the naturally occurring tetrapeptide hymenotoxin-derived peptide series, investigated for its potential modulation of stress and anxiety pathways via sigma-1 receptor interaction without sedative or motor-impairing effects.
• High Purity & Stability
  Delivered as a white to off-white lyophilized powder with ≥ 99 % purity, ensuring consistent experimental reproducibility and stability under proper storage conditions.
• Neuroactive Profile
  Demonstrates activity in preclinical models of emotional regulation and behavioral modulation, with negligible affinity for classical benzodiazepine or GABAergic pathways.
• Flexible Research Utility
  Soluble in aqueous buffers for systemic or central administration in animal models, supporting studies in neurochemistry, behavioral pharmacology, and receptor signaling.

Research Applications

• Anxiety & Mood Studies
  Evaluate sigma-1 receptor modulation and downstream effects on neurotransmitter systems in rodent or primate behavioral models.
• Receptor Pharmacology
  Characterize binding, signaling, and cross-talk with sigma and NMDA receptor complexes in vitro and in vivo.
• Neuroprotection & Stress Response
  Investigate effects on neuroinflammation, oxidative stress, and excitotoxicity in neuronal injury or chronic stress paradigms.
• Cognitive Function
  Explore its influence on learning, memory, and adaptive behavior under experimental conditions.
• Formulation & PK/PD Development
  Assess delivery systems, dosing regimens, and pharmacokinetic profiles for short peptide-based neuroactive compounds.

Specifications