MOTS-c

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Lyophilized MOTS-c Powder

Overview

MOTS-c is a 16‑amino‑acid mitochondrial‑derived peptide encoded within the 12S rRNA, shown to translocate to the nucleus under metabolic stress to regulate nuclear gene expression and promote cellular homeostasis Frontiers.

In rodent models, MOTS-c treatment prevents age‑dependent and high‑fat‑diet‑induced insulin resistance, as well as diet‑induced obesity, demonstrating its role as an active regulator of systemic metabolism PMC.

Human cohort data reveal that plasma MOTS-c levels negatively correlate with fasting insulin, HbA1c, and BMI, indicating clinical relevance to metabolic health PMC.

Key Features

• Insulin Sensitizer: Improves skeletal muscle insulin sensitivity and reduces weight gain in high‑fat‑fed mice, partly via activation of AMPK and increased NAD⁺ levels PMCPMC.

• Exercise Mimetic: Exercise induces endogenous MOTS-c expression in humans, and exogenous MOTS-c treatment enhances physical performance, endurance, and adaptation to metabolic stress in young to old mice Nature.

• Longevity & Aging: Late‑life intermittent MOTS-c administration extends healthy lifespan in aged mice, suggesting potential as a geroprotective agent Diabetes & Metabolism Journal.

• Metabolic Flexibility: Enhances metabolic homeostasis by modulating glycolysis, fatty acid oxidation, and mitochondrial function in muscle and liver tissues PMC.

• Anti‑Inflammatory & Cytokine Modulation: Regulates inflammatory pathways, including IL‑6–dependent POMC transcription, to support immune‑metabolic balance Diabetes & Metabolism Journal.

Applications

• Metabolic Disease Models: Use in in vitro and in vivo studies to probe mechanisms of insulin resistance, obesity prevention, and glucose homeostasis PMC.

• Exercise Physiology: Investigate MOTS-c’s role as an exercise mimetic in muscle metabolism, endurance, and mitochondrial biogenesis assays Nature.

• Aging & Longevity Research: Explore geroprotective pathways, mitochondrial–nuclear crosstalk, and interventions for healthy aging in cell and animal models PMC.

• Cardiometabolic Health: Model peptide effects on lipid profiles, blood pressure, and endothelial function in cardiovascular research Nature.

• Molecular Mechanism Studies: Elucidate MOTS-c’s nuclear gene targets, AMPK activation, and NAD⁺–dependent signaling in biochemical and omics workflows Frontiers.

Specifications