KPV

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Lyophilized KPV Powder

Overview

KPV (Lys–Pro–Val) is a tripeptide fragment derived from α-melanocyte stimulating hormone (α-MSH) renowned for its potent anti-inflammatory and wound-healing properties. By engaging melanocortin receptors without the hormonal side-effects of full-length α-MSH, KPV offers a targeted approach to modulating cytokine release and promoting tissue repair.

Key Features

• Anti-Inflammatory Efficacy: Suppresses TNF-α and IL-6 production in macrophage cultures (PubMed)

• Wound-Healing Promotion: Accelerates re-epithelialization in dermal injury models (PMCResearchGate)

• Antimicrobial Synergy: Enhances bacterial clearance in skin-infection assays (PubMedPubMed)

• Osteoprotective Potential: Reduces osteoclastogenesis in bone-remodeling studies (PMCFrontiers)

• Low Immunogenicity: Minimal antibody generation in repeated-dose protocols (PubMedPMC)

Applications

• Inflammation Models: Cytokine profiling in LPS-challenged macrophages (PMC)

• Wound-Healing Assays: Scratch-wound and full-thickness skin models (PubMed)

• Gastrointestinal Inflammation: Colitis and IBD research in rodent models (Frontiers)

• Dermatological Studies: Psoriasis and dermatitis ex vivo tissue assays (ResearchGate)

• Bone-Remodeling Experiments: Osteoclast/osteoblast co-culture systems (PubMed)