Kisspeptin-10

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Lyophilized Kisspeptin-10 Powder

Overview

Kisspeptin-10 is the decapeptide core of the kisspeptin family, acting as the primary activator of GPR54 (KISS1R) to regulate GnRH secretion and drive the hypothalamic–pituitary–gonadal axis. Its ultrapotent stimulation of LH and FSH release has made Kisspeptin-10 indispensable in reproductive endocrinology and puberty-onset studies.

Key Features

• GnRH/LH Release: Induces robust, dose-dependent LH surges in rodents and primates (PubMed)

• High Potency: Effective at femtomolar concentrations, enabling minimal-dose protocols (PMCResearchGate)

• Rapid Clearance: Short half-life (~30 min) supports tightly controlled pulse-dosing paradigms (PubMedPubMed)

• Blood–Brain Barrier Penetration: Demonstrates central nervous system bioavailability after peripheral injection (PMCFrontiers)

• Safety Profile: No adverse cardiovascular or metabolic effects in acute and repeat-dose studies (PubMedPMC)

Applications

• Reproductive Endocrinology: GnRH neuron activation and LH/FSH release assays (PMC)

• Puberty-Onset Research: Modeling central precocious or delayed puberty in rodents (PubMed)

• Hypogonadism Studies: Therapeutic exploration in male and female gonad-suppressed models (Frontiers)

• Fertility Investigations: Oocyte maturation and sperm motility enhancement assays (ResearchGate)

• Signal-Transduction Mapping: GPR54 receptor binding and downstream pathway analysis (PubMed)