Epithalon

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Lyophilized Epithalon Powder

Overview

Epithalon is a lyophilized tetrapeptide (Ala‑Glu‑Asp‑Gly) originally isolated from the pineal gland, designed to mimic and amplify the body’s natural geroprotective signals PubMed Central. It’s been shown to reactivate telomerase gene expression in telomerase‑negative human fetal fibroblasts, leading to measurable telomere elongation and extended replicative lifespan in vitro PubMed.

Key Features

• Telomerase Reactivation: Induces expression of hTERT and increases telomerase enzymatic activity, facilitating telomere elongation comparable to early‑passage cells PubMed.

• Circadian Reset: In aged rodents and primates, Epithalon elevates nocturnal melatonin levels, helping restore youthful sleep–wake patterns and endocrine homeostasis PubMedPubMed.

• Antioxidant & Neuroprotection: Stimulates expression of superoxide dismutase, ceruloplasmin, and other antioxidant enzymes, while exhibiting antimutagenic and neuroprotective effects in vitro and in vivo ScienceDirect.

• Immune Support: Improves key immunological markers—enhancing lymphocyte proliferation and normalizing cytokine profiles in aging animal models PubMed.

• Proven Geroprotector: Demonstrated lifespan extension in multiple species (rats, mice, and fruit flies) and reduction in age‑related biomarkers, suggesting broad-spectrum anti‑aging potential PubMed.

Applications

• Cellular Senescence Research: Use in fibroblast and stem‑cell cultures to study telomere biology, replicative aging, and epigenetic stability PubMed.

• Circadian Rhythm & Sleep Studies: Explore pineal peptide modulation to correct sleep disorders and age‑related hormonal dysregulation PubMed.

• Oxidative Stress & Neurodegeneration Models: Apply as an antioxidant modulator in assays of neuroprotection, DNA damage response, and mutagenesis prevention.

• Metabolic Aging & Endocrine Function: Investigate effects on glucose and insulin homeostasis in aged cell and animal models PubMed.

• Geroprotective Screening: Integrate into high‑throughput screens for anti‑aging compounds and longevity pathway activators PubMed.

Specifications