AOD-9604

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Lyophilized AOD-9604 Powder

Key Features

• Selective Lipolysis Activation: AOD-9604 upregulates beta-3 adrenergic receptors in fat cells, promoting the breakdown of stored triglycerides into free fatty acids for energy use, without affecting insulin or IGF-1 levels pmc.ncbi.nlm.nih.goven.wikipedia.org.

• Lipogenesis Inhibition: Unlike full-length hGH, AOD-9604 inhibits the conversion of excess calories into new fat deposits, helping to prevent weight gain in high-fat diet models jofem.orgchicagoarthritis.com.

• Oral and Injectable Research Formats: AOD-9604 is available as a stable, lyophilized powder that dissolves easily for in vitro assays or can be formulated for subcutaneous injection in animal studies, providing flexible delivery options for diverse research protocols pmc.ncbi.nlm.nih.govresearchgate.net.

• Favorable Safety Profile: Early human trials indicated that AOD-9604 was well tolerated, with no significant adverse effects on glucose metabolism, cortisol, or IGF-1 levels over 12-week dosing periods jofem.orgen.wikipedia.org.

Applications

• Obesity & Metabolic Research: Evaluate the mechanisms of targeted fat reduction and metabolic enhancement in cell culture and rodent models, including diet-induced obesity and genetically obese phenotypes pmc.ncbi.nlm.nih.govchicagoarthritis.com.

• Lipid Metabolism Studies: Probe beta-3 adrenergic receptor pathways by assessing free fatty acid release, glycerol levels, and gene-expression changes in adipocytes treated with AOD-9604 en.wikipedia.org.

• Pharmacokinetics & Formulation: Optimize dosing regimens, half-life profiling, and delivery methods for sustained peptide action; investigate subcutaneous versus oral bioavailability in preclinical settings jofem.orgresearchgate.net.

• Tissue Repair & Cartilage Research: Explore emerging evidence of AOD-9604’s potential to support cartilage regeneration and joint health by modulating local growth factors and inflammatory mediators youtube.commusechem.com.

• Comparative Peptide Studies: Benchmark AOD-9604 against other fat-targeting peptides (e.g., GLP-1 analogs, GHRH fragments) to delineate unique lipolytic versus anorectic mechanisms chicagoarthritis.comen.wikipedia.org.

Specifications